What are Dry Powder Inhalers?
DPIs are termed dry powder inhalers. The medication in the DPI may be stored in a capsule and broken down or may installed directly in the device. “Once loaded the patient puts mouth piece of inhaler into their mouth and take a deep inhalation holding the amount of dose delivered is less than few tens of milligrams in a single push.” (1)
Who uses Dry Powder Inhalers
Patients that have a respiratory illness such as asthma, bronchitis and emphysema use dry powder inhalers. (1)
Types of Dry Powder Inhalers
There are various DPIs for patients. Capsule based devices consist of a capsule placed in a chamber that is then twisted and breaks the capsule and the patient can then inhale the powder. Various brands of capsule based devices exist such as aerolizer, rotahaler, ARCUS, etc…(1) “The blister based DPIs have a ring of aluminum blister inside the DPI device. Each blister contains the dose of powder drug. Dose is indicated by a dose counter installed in a DPI when the blister is burst by applying external force. Then the drug powder is inhaled by air stream when patient takes the breath.”(1) There are various blister DPI inhalers, but the most common ones are Acu Breathe, Aspirair, Diskhaler, Diskus, Forsipro, Gyrohaler, Microdose DPI, Prohaler, and Votran DPI. Finally, the last type of DPI inhaler is known as a cartridge inhaler. These inhalers have a powder chamber to store the drug and the device has a special mechanism to release the medication. (1) Some examples of cartridge inhalers include Xectovair, Ultrahaler, Spiromax, Swinghaler, Jethaler, E flex, Pulmojet, and VIP inhaler. (1)
Efficacy of Dry Powder Inhalers
The efficacy of DPI is influenced by several factors including their effects when used under optimal conditions, the way they are used (i.e, the appropriateness of the prescription, if the patient is adherent to the medication, and the technique used).(2) A systematic review of literature performed about a decade ago did not find any difference in the efficacy of the different DPIs compared to other devices such as MDIs (metered dose inhalers) and HFAs (hydrofluoroalkane inhalers). (2)
Education on Dry Powder Inhalers
First make sure to insert the capsule inside the chamber of your DPI. Next, twist or press the button that will break down your capsule. After that, make sure to exhale all the way. Then make sure to inhale fast and hard all the particles all the way. Make sure to hold your breath for thirty seconds after inhalation. Now you can exhale. (2)
The most common problems associated with DPI inhalers include “irritation that may cause cough, high moisture can cause clumping of the powder, and blowing into DPI may blow drug out and induce internal humidity.”(1)
(1) Ahsan A, Asif DF, Ghafoor A, Munir H, Nawaz MN. Dry powder inhaler devices. J Cell Sci Ther . 2017;(8)3:1-4. Available from: https://www.omicsonline.org/open-access/dry-powder-inhaler-devices-2157-7013-1000271.pdf . Accessed October 24, 2018
(2) Chrystyn H, Lavorini F, Roche N. Effectiveness of inhaler devices in adult asthma and copd. EMJ Respir . 2013;1:64-71.Available from: http://www.sociedadgrap.com/assets/effectiveness-of-inhaler-devices-in-adult-asthma-and-copd.pdf . Accessed October 24, 2018
My name is Artur Dzhurinskiy and I graduated from St. Louis College of Pharmacy in 2014 with a doctor of pharmacy degree. Through my academics I gained valuable experience learning about various medications that are used to treat disease states. I took pathophysiology, which helped me learn about how diseases in the body progress. I also took four different therapeutics courses, which helped me understand not only disease states, but how to select the proper medications for a disease based on guidelines. My favorite course while at college was pharmacology. I love learning about how medications work and how they affect the body (pharmacodynamics).
I am passionate writing about medications and disease states. I decided to get started with SB Medical because I have the opportunity to educate patients by writing about disease states and medications or medical devices. Hopefully through my writing I can educate patients about their disease states, medications, and medical devices.
I also have an interest in the drug development process and clinical trials. Primary literature is very important because new medications are being developed that could revolutionize the way we treat certain conditions. My main goal in the future is to hopefully write clinical trials and other regulatory documents relating to the drug approval process.
My main hobby includes playing chess. I play chess primarily online. Chess teaches you how to think strategically. Also, chess teaches you how to have a plan or goal in mind, which helps me in writing. The reason for this is because you need an explanation for every move you make in chess; just like you need an explanation for every sentence you write.